The problem of unwanted vaccine interactions.
Does vaccination today represent an immune system roulette game for the future?
Vaccines have been proven to upset the immune system by changing the way it responds to subsequent infections, vaccines also pose an uncontrolled danger when interacting with each other.
The mechanisms for compromising the immune system via vaccine/immune system, vaccine/vaccine, and vaccine/pathogen interactions are not fully understood but they cause considerable health hazards that have been documented on numerous occasions.
Regarding the DTP vaccination, a 2002 study by Aaby reported on the vaccine test in Guinea-Bissau during the war of 1998 when there was no functioning vaccine program in the country and found an interaction between measles and DPT vaccinations that resulted in a 3-fold increase in deaths for girls and it was suggested that girls should be assessed separately from boys. The adverse health impact of the DPT vaccine was confirmed in a later 2012 study by Aaby which found “vaccinated children, particularly girls, had threefold higher mortality between 2 and 6 months of age.” In a subsequent 2018 study Aaby noted that “DTP-vaccinated children had 5-fold higher mortality between 3 and 6 months of age than children not yet vaccinated with DTP” and again this was “particularly for girls.” Aaby found that “studies of the introduction of DTP constitute a clear danger signal that DTP may substantially increase all-cause mortality.”
Regarding the flu vaccine, a 2010 study by Skowronski found an association between flu vaccination in the winter of 2008 and the need for medical attention for H1N1 infection in the summer six months later. A 2012 study by Cowling found in children, the flu vaccine increased the risk 5-fold of suffering from other respiratory infections like coronavirus. A 2019 study by Wolff examined “vaccine-derived virus interference” associated with flu vaccination and found it was “significantly associated with coronavirus and human metapneumovirus.” A 2013 research article by Khurana reported that “vaccine-associated enhanced respiratory disease (VAERD) has been reported in multiple respiratory infections in humans and in animals.”
The CDC explain that “Guillain-Barré syndrome (GBS) is a rare disorder where the body's immune system damages nerve. The damage to the nerves causes muscle weakness and sometimes paralysis. While its cause is not fully understood, the syndrome often follows infection with a virus or bacteria.” The CDC only discuss the link to the 1976 flu vaccine and claim it to be only a slight increase in risk, however, regarding the 2009-2010 flu program, a study by Wise found 1.6 fold increase in GBS, a study by Tolkars found a 2.1 fold overall increase with a 3 fold increase for children aged 6 months to 2 years old, a study by Yih and a study by Salmon found an increase of 2.5 fold increase, and a study by Greene found an increase of 4.4 fold for developing GBS after vaccination. While the increased risk for GBS is not as high for the 2009 vaccine as the 8.8 fold increase of the 1976 version, it can be seen that vaccines do indeed upset the immune system.
Furthermore, vaccines were found to affect the overall health of children, a 2020 study by Hooker found that vaccinated children suffered from signifacantly more developmental delays, asthma, and ear infections than unvaccinated children. A 2011 study by Miller found a linear correlation between the number of vaccines received and the number of infant deaths. A 2012 study by Goldman confirmed this finding. A 2017 pilot study by Mawson found that the vaccinated were less likely to suffer from chickenpox and pertussis, but more likely to have been diagnosed with pneumonia, otitis media, allergies and a 6.6 fold increase risk of neurodevelopmental disorders for preterm babies.
Unwanted vaccine interactions with our immune system has been long understood and a 1999 letter to the editor of the BMJ by Classen asked the question should the public “be told that vaccines may have long-term adverse effects?” Classen cited the development of diabetes after infant vaccination as one of those long-term effects. Classen reports that “research into immunisation has been based on the theory that the benefits of immunisation far outweigh the risks from delayed adverse events and so long-term safety studies do not need to be performed.”
Not only are the interaction of vaccines with other diseases not understood but there can be no way of knowing how the human immune system is going to react to newly immerging diseases like COVID-19 in the vaccinated.
A 2020 study by Miller found that somehow the BCG vaccine protected against COVID-19 deaths while a 2021 study by Afify found deaths from COVID-19 occurred more often in those vaccinated against polio.
From the information shared here, it can be seen that many long-term health hazards exist from vaccination and the interactions between vaccination and subsequent diseases show that, when assessing the overall health benefit, to only consider the target disease does not give a broad enough understanding for assessment of any real-life long-term health risks.
The human immune system is not being considered as a whole when the health benefit of a vaccine is assessed. While some vaccines may help prevent the target disease the changes in immune response have been found to compromise the immune system, which can result in unfavourable outcomes for the vaccinated.
References:
Aaby, P., Jensen, H., Garly, M.L., Balé, C., Martins, C. and Lisse, I., 2002. Routine vaccinations and child survival in a war situation with high mortality: effect of gender. Vaccine, 21(1-2), pp.15-20. Available from https://pubmed.ncbi.nlm.nih.gov/12443658/
Aaby, P., Ravn, H., Roth, A., Rodrigues, A., Lisse, I.M., Diness, B.R., Lausch, K.R., Lund, N., Rasmussen, J., Biering-Sørensen, S. and Whittle, H., 2012. Early diphtheria-tetanus-pertussis vaccination associated with higher female mortality and no difference in male mortality in a cohort of low birthweight children: an observational study within a randomised trial. Archives of disease in childhood, 97(8), pp.685-691. Available from https://adc.bmj.com/content/97/8/685.short
Aaby, P., Mogensen, S.W., Rodrigues, A. and Benn, C.S., 2018. Evidence of increase in mortality after the introduction of diphtheria–tetanus–pertussis vaccine to children aged 6–35 months in Guinea-Bissau: a time for reflection?. Frontiers in public health, 6, p.79. Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868131/
Afify, M.A., Alqahtani, R.M., Alzamil, M.A.M., Khorshid, F.A., Almarshedy, S.M., Alattas, S.G., Alrawaf, T.N., Bin-Jumah, M., Abdel-Daim, M.M. and Almohideb, M., 2021. Correlation between polio immunization coverage and overall morbidity and mortality for COVID-19: an epidemiological study. Environmental Science and Pollution Research, pp.1-8. Available from https://pubmed.ncbi.nlm.nih.gov/34089456/
Cowling, B.J., Fang, V.J., Nishiura, H., Chan, K.H., Ng, S., Ip, D.K., Chiu, S.S., Leung, G.M. and Peiris, J.M., 2012. Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine. Clinical Infectious Diseases, 54(12), pp.1778-1783. Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404712/
CDC - GBS (Guillain-Barré Syndrome) and Vaccines | Vaccine Safety | CDC (2021). Cdc.gov. Available from https://www.cdc.gov/vaccinesafety/concerns/guillain-barre-syndrome.html [Accessed 28 October 2021].
Classen, J.B. and Classen, D.C., 1999. Public should be told that vaccines may have long term adverse effects. BMJ, 318(7177), p.193. Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1114674/?fbclid=IwAR2q2bnXxdyXXSZU9iKNnHbgeyGNyoyjR7lmcDYO4IYKmTlcpoRwR-nKFdw
Goldman, G.S. and Miller, N.Z., 2012. Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990–2010. Human & experimental toxicology, 31(10), pp.1012-1021. Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547435/
Greene, S.K., Rett, M., Weintraub, E.S., Li, L., Yin, R., Amato, A.A., Ho, D.T., Sheikh, S.I., Fireman, B.H., Daley, M.F. and Belongia, E.A., 2012. Risk of confirmed Guillain-Barré syndrome following receipt of monovalent inactivated influenza A (H1N1) and seasonal influenza vaccines in the Vaccine Safety Datalink Project, 2009–2010. American journal of epidemiology, 175(11), pp.1100-1109. Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272801/
Hooker, B.S. and Miller, N.Z., 2020. Analysis of health outcomes in vaccinated and unvaccinated children: Developmental delays, asthma, ear infections and gastrointestinal disorders. SAGE Open Medicine, 8, p.2050312120925344. Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268563/
Khurana, S., Loving, C.L., Manischewitz, J., King, L.R., Gauger, P.C., Henningson, J., Vincent, A.L. and Golding, H., 2013. Vaccine-induced anti-HA2 antibodies promote virus fusion and enhance influenza virus respiratory disease. Science translational medicine, 5(200), pp.200ra114-200ra114. Available from https://pubmed.ncbi.nlm.nih.gov/23986398/
Mawson, A.R., Ray, B.D., Bhuiyan, A.R. and Jacob, B., 2017. Pilot comparative study on the health of vaccinated and unvaccinated 6-to 12-year-old US children. J Transl Sci, 3(3), pp.1-12. Available from https://www.researchgate.net/profile/Anthony-Mawson/publication/317086531_Pilot_comparative_study_on_the_health_of_vaccinated_and_unvaccinated_6-to_12-year-old_US_children/links/5924d0af458515e3d423eb87/Pilot-comparative-study-on-the-health-of-vaccinated-and-unvaccinated-6-to-12-year-old-US-children.pdf
Miller, A., Reandelar, M.J., Fasciglione, K., Roumenova, V., Li, Y. and Otazu, G.H., 2020. Correlation between universal BCG vaccination policy and reduced mortality for COVID-19. MedRxiv. Available from https://www.medrxiv.org/content/10.1101/2020.03.24.20042937v2
Miller, N.Z. and Goldman, G.S., 2011. Infant mortality rates regressed against number of vaccine doses routinely given: Is there a biochemical or synergistic toxicity? Human & Experimental Toxicology, 30(9), pp.1420-1428. Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170075/?fbclid=IwAR2HvzzUNbQ7aQaH0Id3wPioq-Y95kQhsmwAeUYAEY4p8r_7KItMRtOp60U
Salmon, D.A., Proschan, M., Forshee, R., Gargiullo, P., Bleser, W., Burwen, D.R., Cunningham, F., Garman, P., Greene, S.K., Lee, G.M. and Vellozzi, C., 2013. Association between Guillain-Barré syndrome and influenza A (H1N1) 2009 monovalent inactivated vaccines in the USA: a meta-analysis. The Lancet, 381(9876), pp.1461-1468. Available from https://pubmed.ncbi.nlm.nih.gov/23498095/
Skowronski, D.M., De Serres, G., Crowcroft, N.S., Janjua, N.Z., Boulianne, N., Hottes, T.S., Rosella, L.C., Dickinson, J.A., Gilca, R., Sethi, P. and Ouhoummane, N., 2010. Association between the 2008–09 seasonal influenza vaccine and pandemic H1N1 illness during spring–summer 2009: four observational studies from Canada. PLoS medicine, 7(4), p.e1000258. Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850386/
Tokars, J.I., Lewis, P., DeStefano, F., Wise, M., Viray, M., Morgan, O., Gargiullo, P. and Vellozzi, C., 2012. The risk of Guillain–Barré syndrome associated with influenza A (H1N1) 2009 monovalent vaccine and 2009–2010 seasonal influenza vaccines: results from self‐controlled analyses. Pharmacoepidemiology and drug safety, 21(5), pp.546-552. Available from https://pubmed.ncbi.nlm.nih.gov/22407672/
Wise, M.E., Viray, M., Sejvar, J.J., Lewis, P., Baughman, A.L., Connor, W., Danila, R., Giambrone, G.P., Hale, C., Hogan, B.C. and Meek, J.I., 2012. Guillain-Barré syndrome during the 2009–2010 H1N1 influenza vaccination campaign: population-based surveillance among 45 million Americans. American journal of epidemiology, 175(11), pp.1110-1119. Available from https://pubmed.ncbi.nlm.nih.gov/22582209/
Wolff, G.G., 2020. Influenza vaccination and respiratory virus interference among Department of Defense personnel during the 2017–2018 influenza season. Vaccine, 38(2), pp.350-354. Available from https://pubmed.ncbi.nlm.nih.gov/31607599/
Yih, W.K., Lee, G.M., Lieu, T.A., Ball, R., Kulldorff, M., Rett, M., Wahl, P.M., McMahill-Walraven, C.N., Platt, R. and Salmon, D.A., 2012. Surveillance for adverse events following receipt of pandemic 2009 H1N1 vaccine in the Post-Licensure Rapid Immunization Safety Monitoring (PRISM) System, 2009–2010. American journal of epidemiology, 175(11), pp.1120-1128. Available from https://pubmed.ncbi.nlm.nih.gov/22582207/